This paper shows how key aspects of Aristotle’s core concepts of matter and motion, some of which have recently been shown to help make sense of quantum mechanical indeterminacy, align with some important results of the energy-momentum relationship of special relativity. In this conception, mobility and indeterminacy are inherently linked to each other and to materiality. Applying these ideas to massless particles, which relativity tells us move at the maximal cosmic speed, allows us to draw the conclusion that they must (...) be the most basic physical bodies, that is, mobile substances. The most familiar massless particle, the photon, constitutes light. Furthermore, because the photon composes luminous matter but cannot be decomposed into anything else more basic, it fulfills the definition of element. (shrink)

Philipp W. Balsiger / Rudolf Kötter Die Kultur moderner Wissenschaft am Beispiel Albert Einstein Für alle, die über den Tellerrand der Physik EInsteins blicken wollen Albert Einstein ist ein wissenschaftshistorisches Musterbeispiel dafür, wie wissenschaftliche Kulturleistungen bei der Entwicklung neuer Theorien, in persönlichen Netzwerken und im Zusammenhand mit philosophischem Denken entstehen. Dieses Buch enthält Beiträge von Physikern, Philosophen und Wissenschaftshistorikern, die überraschend vielseitigen Facetten der physikalischen Kultur am Beispiel Albert Einsteins zusammentragen: von den Paradigmenwechseln des Raum- Zeitverständnisses über die Philosophie (...) in der Physik bis hin zur Bildungs- und Popularisierungskultur, die mit seinem Wirken verbunden ist. (shrink)

Name der Zeitschrift: Byzantinische Zeitschrift Jahrgang: 108 Heft: 2 Seiten: 827-844.

Riehl, A. Zu R. Hayms gedächtnis.--Schrader, W. Die seelenlehre der Griechen in der älteren lyrik.--Vaihinger, H. Die transcendentale deduktion der kategorien.--Rehmke, J. Wechselwirkung oder parallelismus?--Wentscher, M. Das problem der willensfreiheit bei Lotze.--Kühnemann, E. Über die grundlagen der lehre des Spinoza.--Volkelt, J. Die kunst des individualisierens in den dichtungen Jean Pauls.--Uphues, G. Über die idee einer pädagogik als bildungswissenschaft. Über die idee einer philosophie des christentums.--Lipps, T. Von der form der ästhetischen apperception.--Schwarz, H. Gefallen und lust.--Medicus, F. Die beiden prinzipien der (...) sittlichen beurteilung.--Reischle, M. Jesu worte von der ewigen bestimmung der menschenseele in religionsgeschichtlicher beleuchtung. (shrink)

Depletion of mitochondrial endo/exonuclease G‐like (EXOG) in cultured neonatal cardiomyocytes stimulates mitochondrial oxygen consumption rate (OCR) and induces hypertrophy via reactive oxygen species (ROS). Here, we show that neurohormonal stress triggers cell death in endo/exonuclease G‐like‐depleted cells, and this is marked by a decrease in mitochondrial reserve capacity. Neurohormonal stimulation with phenylephrine (PE) did not have an additive effect on the hypertrophic response induced by endo/exonuclease G‐like depletion. Interestingly, PE‐induced atrial natriuretic peptide (ANP) gene expression was completely abolished in endo/exonuclease (...) G‐like‐depleted cells, suggesting a reverse signaling function of endo/exonuclease G‐like. Endo/exonuclease G‐like depletion initially resulted in increased mitochondrial OCR, but this declined upon PE stimulation. In particular, the reserve capacity of the mitochondrial respiratory chain and maximal respiration were the first indicators of perturbations in mitochondrial respiration, and these marked the subsequent decline in mitochondrial function. Although pathological stimulation accelerated these processes, prolonged EXOG depletion also resulted in a decline in mitochondrial function. At early stages of endo/exonuclease G‐like depletion, mitochondrial ROS production was increased, but this did not affect mitochondrial DNA (mtDNA) integrity. After prolonged depletion, ROS levels returned to control values, despite hyperpolarization of the mitochondrial membrane. The mitochondrial dysfunction finally resulted in cell death, which appears to be mainly a form of necrosis. In conclusion, endo/exonuclease G‐like plays an essential role in cardiomyocyte physiology. Loss of endo/exonuclease G‐like results in diminished adaptation to pathological stress. The decline in maximal respiration and reserve capacity is the first sign of mitochondrial dysfunction that determines subsequent cell death. (shrink)